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Tong learned from famous European embryologists when studying in Belgium, published several papers after careful observation and researches, which exerted great effects on the biological field of Europe at that time. He made systematic studies of sea squirts and amphibiology, especially the growth of fish ovum. He put forth the idiographic idea that fish ovum does not have the equal growth ability in the budding period. He also made breakthroughs in the biological study and researches, found new ways to control fish's hereditary variation.
Tong was successively the professor of Shandong University, Medical College of China Central University, Tongji University and Fudan University; researcher of China Research Institute of Psychology and Physiology, Cambridge University and Yale University; Vice President of Shandong University, Director of the Institute of Oceanology, Director of the Institute of Zoology and Vice President of China Academy of Sciences. Tong was also the member of standing committee of National People's Congress of the third and fourth sessions, and the vice president of the Chinese People's Political Consultative Conference (CPPCC).