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Qian returned to China in 1955. After his return, Qian has served successively as director-general with the mechanics institute of Chinese Academy of Sciences, deputy director-general and director-general with the fifth research institute of the State Defense Ministry, vice chairman with the Seventh Design and Research Institute The Ministry of Machinery Industry, deputy director-general with the Commission of Science, Technology and Industry for National Defense, president with the 3rd China Association for Science and Technology, vice president with the 6th to the 8th Chinese People's Political Consultative Conference (CPPCC). Currently, Qian is the senior consultant with the Commission of Science and Technology of the General Equipment Ministry of the People's Liberation Army, honorary president with China Association for Science and Technology. In 1957, Qian won the first prize of the natural science by Chinese Academy of Sciences, in 1979, the outstanding alumnus prize by California Institute of Technology, in 1985, first prize of national advanced technology awards, in 1989, the title of "World's Celebrity for Sciences and Engineering", and in 1991, China's outstanding scientist with outstanding achievements and the nation's first-grade medal for heroic models.
In 1956, Qian put forward "Proposal on the Development of China's Aviation Industry for National Defense" and assisted Zhou Enlai, the then premiere, and Marshal Nie Rongzheng to prepare the establishment of China's first missile and rocket R&D structure, the Fifth Research Institute of State Ministry of Defense. In October 1956, Qian assumed office of director-general with the fifth research institute. Henceforth, Qian has long been in charge of the chief technological officer with the R&D of China's missile, rocket and spacecraft, and has contributed greatly to the establishment and development of China's missile, rocket and spacecraft undertakings. Qian is a forerunner pioneering the development of China's aerospace science and technology. He has been honored as "Father of China's Missile".